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From the sample: Cellular Respiration — lecture notes, week 4
Cellular Respiration — lecture notes, week 4 — A two-page handout on how cells release energy from glucose. Every answer above is checkable against this text. These sample questions were written by hand from the passage to show the format and depth; upload a file to see what the model itself produces.
Cellular respiration is the process by which cells break down glucose and use the energy released to make ATP. The overall reaction is C6H12O6 + 6 O2 → 6 CO2 + 6 H2O, with energy released as ATP and heat.
It proceeds in three stages. Glycolysis takes place in the cytoplasm and splits one six-carbon glucose molecule into two three-carbon pyruvate molecules, with a net yield of 2 ATP and 2 NADH. Glycolysis does not require oxygen.
Each pyruvate is then transported into the mitochondrial matrix and oxidised to acetyl-CoA, releasing one molecule of carbon dioxide and reducing NAD+ to NADH.
The citric acid cycle, also called the Krebs cycle, runs in the mitochondrial matrix. Each turn releases 2 CO2 and produces 3 NADH, 1 FADH2 and 1 ATP. Because one glucose yields two acetyl-CoA molecules, the cycle turns twice per glucose.
Finally, oxidative phosphorylation occurs at the inner mitochondrial membrane. NADH and FADH2 donate electrons to the electron transport chain, and the energy released is used to pump protons into the intermembrane space. The resulting gradient drives ATP synthase, a process called chemiosmosis. Oxygen is the final electron acceptor and is reduced to water.
In total, one glucose molecule yields roughly 30 to 32 ATP in a eukaryotic cell. When oxygen is unavailable, human muscle cells fall back on lactic acid fermentation, which produces no additional ATP itself but regenerates NAD+ so that glycolysis can continue.
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